Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis

Citation

Evidence Type: Research (Data Analysis)
Kaye JA, del Mar Melero-Montes M, Jick H. Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis. BMJ. 2001;322(7284):460–3 - Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis. - PubMed - NCBI Score: 0.0/0.0

Discussion

The research looked at information for all children 12 years or under who were diagnosed with autism between 1988 and 1999 in the UK, with further analysis for boys aged 2 to 5 years born between 1988 and 1993. The research found that the rate of autism rose sharply without any regard for rate of vaccination. While the ultimate cause of the increase remains unknown after this research it is not correlated with the MMR vaccine.

Strengths/Weaknesses

Conclusions

Strength/Weakness 1

The authors have no known ties to the vaccine industry, but there may be strong ties between the organisation responsible for the research and manufacturers.


Strength/Weakness 2

The organisation which ran this research, The Boston Collaborative Drug Surveillance Program is funded in part by companies which manufacture and sell vaccines.


Strength/Weakness 3

Mild strength: Adequate Sample Size

305 diasnoses of autism were included in the research, a respectable sample size.


Strength/Weakness 4

Strong strength: Well Designed Research

The researchers admitted the number of unvaccinated diagnoses was small enough to make a direct vaccinated vs. unvaccinated comparison statistically insignificant. Instead, they looked at the available data as rate of vaccination against rate of diagnoses over time. Knowing the limitations of your data and adusting your methods are signs of good analysis.


Conclusion 1

The research found no link between the MMR vaccine and autism diagnoses.


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