Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association

Citation

Evidence Type: Research (Data Analysis)
Taylor B, Miller E, Farrington CP, Petropoulos MC, Favot-Mayaud I, Li J, et al. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet. 1999;353(9169):2026–9 - Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. - PubMed - NCBI Score: 0.0/0.0

Discussion

Comparing 498 cases of autism in the UK showed:

  • A gradual increase in reporting of autism rather than a sudden step as would be expected if the MMR were responsible
  • Those vaccinated before 18 months, after 18 months, or not vaccinated started experiencing symptoms at the same ages
  • There was no consistent time between vaccination and onset of symptoms
  • Developmental regression did not cluster in the months following vaccination

Strengths/Weaknesses

Conclusions

Strength/Weakness 1

Strong strength: Well Designed Research

The research went to significant lengths to look for multiple ways clustering could occur and/or be measured.


Conclusion 1

The research showed no difference in age of onset of symptoms regardless of age of vaccination.


Conclusion 2

The research demonstrates no link between MMR vaccination and autism.


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