A population-based study of measles, mumps, and rubella vaccination and autism.

Citation

Evidence Type: Research (Data Analysis)
Madsen KM, Hviid A, Vestergaard M, Schendel D, Wohlfahrt J, Thorsen P, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med. 2002;347(19):1477–82. - A population-based study of measles, mumps, and rubella vaccination and autism. - PubMed - NCBI Score: 0.0/0.0

Discussion

This research makes use of information from the Danish Civil Registration System for 537,303 children between January 1991 through December 1998. This research found no link between time of vaccination and time of diagnosis, and no link between vaccinating and autism prevalence.

Strengths/Weaknesses

Conclusions

Strength/Weakness 1

Mild weakness: Industry Independence

The study was partially funded by vaccine groups and the lead author works for the Danish Epidemiology Science Center. There is not any indication that anything other than pure facts and figures representing reality are present in the results.


Strength/Weakness 2

The research was funded by grants from the Danish National Research Foundation; the National Vaccine Program Office and National Immunization Program, Centers for Disease Control and Prevention; and the National Alliance for Autism Research.


Strength/Weakness 3

Strong strength: Well Designed Research

A great deal of effort appears to have been put into ensuring the data used is accurate and that the results are meaningful.


Strength/Weakness 4

Strong strength: Adequate Sample Size

This study covers 537,303 children, a large sample set


Conclusion 1

The study shows no link between the MMR vaccine and autism prevalence


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