Lack of association between measles virus vaccine and autism with enteropathy: a case-control study.

Citation

Evidence Type: Research (Generic)
Hornig M, Briese T, Buie T, Bauman ML, Lauwers G, Siemetzki U, et al. Lack of association between measles virus vaccine and autism with enteropathy: a case-control study. PLoS ONE. 2008;3(9):e3140 - Lack of association between measles virus vaccine and autism with enteropathy: a case-control study. - PubMed - NCBI Score: 0.0/0.0

Discussion

It has been claimed that presence of measles virus RNA in the bowel is associated with autism, and that this is an indication that the MMR vaccine causes autism. This study provides evidence to indicate evidence that measles RNA is not associated with autism, so claiming that the MMR virus causes autism via this link is even less likely than it already was.

Strengths/Weaknesses

Conclusions

Strength/Weakness 1

Strong strength: Well Designed Research

The testing was performed by three separate laboratories, each of which were blinded to the diagnosis of the patients in the first place. This helps to prevent any possible mistakes from any one laboratory and any bias which could be present in the testing processes. In the end each laboratory came to the same conclusion demonstrating that the samples were likely tested correctly.


Strength/Weakness 2

The testing was performed by three separate laboratories, each of which were blinded to the diagnosis of the patients in the first place. This helps to prevent any possible mistakes from any one laboratory and any bias which could be present in the testing processes. In the end each laboratory came to the same conclusion demonstrating that the samples were likely tested correctly.


Strength/Weakness 3

Mild weakness: Industry Independence

The testing was performed by three separate laboratories, each of which were blinded to the diagnosis of the patients in the first place. This helps to prevent any possible mistakes from any one laboratory and any bias which could be present in the testing processes. In the end each laboratory came to the same conclusion demonstrating that the samples were likely tested correctly.


Conclusion 1

The study provides strong evidence that measles RNA has no correlation with autism.


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